Characterization, biocompatibility, and optimization of electrospun SF/PCL composite nanofiber films

Abstract In this study, composite nanofiber films for the wound dressing application were prepared with silk fibroin (SF) and polycaprolactone (PCL) by electrospinning techniques, SF/PCL characterized combined techniques of scanning electron microscopy (SEM), equilibrium water content, Fourier transform infrared spectrometer test, X-ray diffraction (XRD) cell viability test. The results indicated several parameters, including rotating roller speed, solution concentration, ratio, affected nanofibers’ diameter size, distribution, wettability. manifested a smaller fiber more uniform nanofibers than pure PCL nanofibers. contact angle changed from 121 ± 2° neat to full wetting 40% at 2,000 rpm, indicating good hydrophilicity. Meanwhile, cells exhibit adhesion proliferation on films. These testified that may provide wettability proliferation. It was suggested optimized could be used as potential biological skin healing.